Aled Davies - Autogenous vaccines item on the BBC

Aled Davies - Autogenous vaccines item on the BBC

Autogenous vaccines (formerly known as autovaccines) are therapeutic vaccines, individually tailored for a patient or animal. These vaccines are made from cultures of pathogenic micro-organisms which are isolated from the site of an infection (furuncle, boils, abscess, urine).

On the 18th January, 2017, the article that featured Aled Davies, interviewed by the BBC One Show about alternatives to antibiotics in agriculture was aired. The week before, and a fortnight before, Aled had received emails, both on a Thursday stating that the feature would go out on the programme that evening. He diligently proclaimed the impending airing via social media, but the item was pulled on both occasions. He claims the "no-show" on two occasions made him very nervous. "Being filmed for an item on national television, you are at the mercy of the editor. I just wanted what I said to be properly represented, with useful soundbites making the feature as opposed to being deposited to the edit floor. When the item finally went out, I did feel a relief. Autogenous vaccines are a great tool in the prevention of disease, but my point about finding and negating the source of infection did come through."

Pruex works with farmers to find such pathogenic bacterial infections and negate their ability to infect farm animals and staff.

View the article here on the BBC iPlayer. (It starts 32 minutes in to the programme.)





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Prevention or Cure?

In a modern agricultural context both animal welfare and production gains can be achieved by developing strategies to limit the effect of bacterial infections on farm. The starting point has to be based on evidence. Only by knowing which bacteria cause infections can farmers start to break the cycle of infection, cure and re-infection.
The alternative is to invest in treating every animal with a medicinal treatment, be that a bacterial vaccine, or antibiotic. Both of these treatments are given post an infection. Preventing the ability of bacteria to infect an animal is a key and achievable aim.
Pruex work with farmers to do three things:
1 Find evidence as to which bacteria are causing problems on farm
2 Based on the evidence generated, develop cleaning strategies to prevent infectious bacteria from building colonies
3 Inform consumers of good work done on farm to limit the risk of anti-microbial resistance from over use of antibiotics.
Farmers looking to develop strategies to ensure Prudent as opposed to Excessive antibiotic use should contact Pruex for more information.

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Nuffield UK Winter Conference presentation

Aled Rhys Davies gave a presentation on "Alternatives to Antibiotics in Agriculture" at the Nuffield UK winter conference. View it below:

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The Dairy Farmer publish an article on Pruex.

The December issue of The Dairy Farmer features Pruex.  A link to the online version will be posted once it becomes available.









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Farmers Guardian at the Nuffield Conference

Farmers Guardian at the Nuffield Conference

This year’s Nuffield Farming Scholarship Trust annual conference saw last year’s scholars showcase their findings at a packed event in Newcastle. Vickie Robinson and Ben Briggs report.
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Colostrum is king

The Nuffield Farming Conference was recently held in Newcastle Upon Tyne. Presenting his findings on "Alternatives to Antibiotics in Agriculture" was Aled Rhys Davies of Pruex. 

Delegates learned of the issues of Antimicrobial Resistance (AMR), that have arisen from human misuse, but could well be blamed on agriculture unless the industry develop strategies to ensure prudent as opposed to excessive use of antibiotics. Aled stated that "We have evolved in line with bacteria, around 50% of a humans' body is made up of bacterial cells, so, we can't live without bacteria."

A lively questions and answers session followed where Aled was asked his opinion of improved genetics in the fight against AMR. His answer, which highlighted that bacteria breed faster than cows, eluded to the importance of using the genetics farmers already have to limit any risk of AMR, by working with their livestocks' defence systems to prevent infection or to limit the effect of an infection on the animal. For example, giving colostrum from dairy cows that don't have any bad bacteria in their udders and low somatic cell counts to newborn calves. These cows have the best immunity to the bugs present on the farm. There are two other types of dairy cows on the same farms:

  •  Cows with bad bacteria in their udders and low somatic cell counts
  • Cows with bad bacteria in their udders and high somatic cell counts.

Neither of these cows demonstrate strong resilience to the bugs on the farm. The solution therefore is to:

  • Identify the cows with the best resistance to the bad bugs on the farm
    • Using the Herd Screen system from Pruex
  • Collect and store their colostrum to ensure each calf gets the best chance of developing an immunity that can cope with the bad bugs on the farm
    • Using the ColostroStart system from Pruex

Herd Screen is a product that forms part of a programme that ensures prudent use of antibiotics.

More information on ColostroStart can be gained from this video:




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Medica a source of new products and technologies

Antimicrobial Resistance (AMR), in human healthcare was a hot topic today at the Medica World Forum for Medicine held in Düsseldorf, Germany. The international delegation of attendees confirmed the global nature of the problem.

Twenty percent of the event floor space was dedicated to laboratory equipment and diagnostics. Every stand demonstrating diagnostic equipment or consumables seemed to be swamped by visitors.

At the event, Pruex were able to source some very interesting products to aid the prevention of microflora infection of both animals and humans. More details will follow soon.

There were some fantastic products on show from both British and Irish companies. Pruex would like to wish them all well over the next 3 days.

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The need for evidence based use of antibiotics

Prudent as opposed to excessive use of antibiotics is the safest way to limit Anti-microbial Resistance (AMR), according to Aled Rhys Davies, the Managing Director of Pruex Ltd. 

Currently, in the UK, Doctors, Dentists and Veterinarians can prescribe antibiotics for treatment of bacterial infections. Vets being involved with prescribing antibiotics for food producing animals as well as pets.

Antibiotic useHowever, this is not the case in other countries. In some African countries for example, the latest antibiotics can be purchased from pharmacies without prescription. If the purchaser has no need for the said antibiotic, or doesn't complete the course correctly, then there is a real threat of the bacteria in their bodies becoming resistant to the antibiotic used. That resistant bacteria can spread to other people rendering the antibiotic ineffective for future use. 

It is often difficult to know if a patient, animal or human, has a bacterial or a viral infection. Treating a virus with an antibiotic is futile as it has no effect. However, it is also dangerous as bacteria within the patients body might develop a resistance to the antibiotic given.

Vets have to be extra vigilant when it comes to food producing animals. The antibiotics used have a withdrawal period. The food produced by the animals can't enter the food chain before the completion of the withdrawal period.

Withdrawal period

Compliance with this rule is strictly governed. It prevents food products with traces of antibiotics reaching the food chain. However, this strategy alone is not the end of the story. Vets also have to be sure that there is a need for the antibiotic treatment in the first place in order to fully limit the risk of AMR.

Evidence of need

If antibiotics are prescribed and administered to animals that don't have a bacterial infection the antibiotic can combat, then the risk of generating AMR increases. Only by identifying the bacteria causing an infection can prudent use of antibiotics be achieved as a means of treating a disease and limiting the risk of AMR.

Pruex works with veterinarians and farmers to quickly identify the bacteria causing infections in food producing animals. By generating this evidence, only the animals that need treating with antibiotics are actually treated. There is no longer a need to second guess if treatment is necessary. By limiting the risk of infection on farm and by reducing the infection pressure on animals, consumers can feel reassured that the food they purchase has been produced with optimum animal welfare, optimum production efficiencies and in a way that minimises the threat of AMR.


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