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That is a question that Pruex Ltd has been examining over the last four years. The company aims to lead the fight against anti microbial resistance (AMR), and was set up by Aled Rhys Davies as a result of conducting a Nuffield Farming Scholarship looking at antibiotic use in agriculture and aquaculture. Pruex advocates Prudent as opposed to Excessive antibiotic use.

“In assessing the limited available data around this issue, we realised that there were other questions that needed answering. For example, how much does teat end damage account for in high Somatic Cell Count (SCC), chronic and/or clinical cases of mastitis? Are the biocide chemicals applied to cows teats pre milking in an attempt to achieve sterility not only detrimental to the skin integrity of the teat, but also to the taste of the end product, either as fresh milk or as processed food? What happens in nature, and is there a way to introduce natural products into our modern milk production to limit the need for antibiotic treatment of bacterial infections? Says Aled Davies

In 2019, Pruex were commended an Antibiotic Guardian award by Public Health England for the innovative work they conduct in agriculture. “Good science is based on observations. We take our inspiration from nature. The cows’ udder won’t be sterile when the calf goes to suck, it would probably be coated in soil that won’t cause any infection danger for the calf. The cow, sensing the presence of the calf lets down its milk allowing the flow on nutrition to the calf without damaging the cows’ teat end.  Clinical mastitis cases in nature are few and far between as a result.“ Says Mr. Davies

Modern milk production does differ quite substantially from the natural model. The cow doesn’t sense the presence of the calf, so has to be stimulated to let down its milk. Application and sometimes removal of biocides to teat surfaces by brush, foam, spray or cloth can help the process of stimulating milk let down whilst attempting to achieve sterility. But sub clinical, chronic and clinical infections are prevalent within the industry. The vacuum or pulsation used in the milking process can quickly damage a teat end if the cow doesn’t let down her milk resulting in as site of potential infection post milking. The National Mastitis plan indicates that 35 cases per 100 cows is a target that farmers should look to achieve. That suggests that on many farms, there are greater than 35% of cows infected annually. This data assumes that any cow with a SCC over 200 is regarded as having a sub clinical infection.

“In Switzerland and France, there is a different product used pre milking. Wood Wool, a tangled mess of thin strips of planed wood, similar in look to thin spaghetti, or the timber equivalent of wire wool. Yes, the sap in the wood has biocide properties, but the objective of using a good handful to brush the udder ahead of milking is mainly to stimulate milk let down. By brushing the udder, you remove dirt, and the sensation of the wood wool rubbing the skin of the udder must resemble that of a calf attempting to suck as the cow lets down its milk rapidly.” Says Mr. Davies

Two scientific trials, one from Switzerland and the other from France confirmed that Wood Wool cleaning of udders pre milking resulted in less udder infections as measured by SCC than biocide cleaning. “This does suggest that the speed of milk let down is an important factor in reducing udder infections on dairy farms, and is the main reason that we at Pruex supply this natural product to our customers” Says Mr.Davies

Pruex are a One Health company that look to inspire Prudent as Opposed to Excessive antibiotic use in Human and animal markets.

In December 2020, poultry farms in the United Kingdom experienced a lockdown due to the growing threat of bird flu. Farmers are having to keep their birds shut inside buildings that just aren’t designed for poultry to be housed in 24/7.

Pruex work with farmers to FIND the cause of disease, FIX using our toolbox and TELL the good story being done by farmers. Here is a bit about what we have been finding on poultry farms over the last few months.

1. FIND

What we have found during the bird flu lockdown is that professional free range systems and even back yard poultry keepers have sheds and buildings that are not designed for birds to be housed in 24/7.

We are discovering that ventilation is being affected by pop holes having to stay closed and this subsequently effects the airflow, temperature, humidity and gases within poultry sheds.

Birds are having to be kept in closer proximity than they usually would be, resulting in faeces and moisture building up quickly and litter becoming wetter.

E.Coli and other disease causing bacteria are found naturally in livestock environments, however by keeping animals housed 24/7, we are removing them further and further from their ‘natural’ environments. This is where we experience problems. Increases in moisture within buildings can lead to increases in the build up of harmful disease-causing biofilms dominating our animal environments. Biofilms can develop beneath litter, on cladding and within the water systems, which we ultimately see resulting in increased disease and reduced production in animals.

We use bacteriology and sensor analysis to identify the causes of disease on individual farms.

2. FIX

In the unprecedented times poultry farmers are experiencing, Pruex work to bring some nature back inside the poultry shed.

When birds are able to range on pasture, they get contact with soil bacteria on their feet and beaks. When they are housed, the litter they stand on and scratch in is often dominated with harmful bugs which are challenging their immune systems.

Pruex work to add beneficial bacteria INSIDE poultry sheds to dominate the environment with non-infective bacteria and reduce the risk of harmful biofilms dominating. This can be done using our varied toolbox to fix the problems we find on our initial visits.

We spray bacteria in to sheds and dominate water with beneficial bacteria, this can be done manually or using automated equipment. We supply enrichment bales which have added Pruex bacteria, to replicate scratching in the soil. We are able to reduce the risk of harmful biofilms dominating whist the birds are still in the shed!

3. TELL

The farmers we work with tell us of the benefits they see in their animals, including reduced need for antibiotics, reduced mortality and increased production. Litter stays drier, last longer and air quality improves. This also improves the working environment for staff.

It is our role to spread this good message within agriculture, and to consumers of food raised with optimum levels of animal welfare.  

Please get in touch for more information. 01558 509025. www.pruex.co.uk

Jack Foulks and his Family farm in Anglesey running a flock of 3,000 Suffolk cross Texel cross mule breeding ewes lambing in February. 

Due to a high rainfall area lambing takes place indoors between the months of January and early April, with the majority of lambs born in February. Ewes are housed from the start of December. “Before implementing the Pruex 5 point plan in 2019 we did
have a problem with E Coli scours in the lambs and numerous cases of joint ill. We didn’t loose many lambs, but did have to use more antibiotics than we’d want to limit the problem.” Said Jack. Each lamb was given an oral antibiotic treatment along with a penicillin injection. “Our successes in reducing our issues aren’t purely down to using Pruex products to ensure a dry bed, clean air and pure water, we have also worked on the nutrition of the ewes with the renowned vet Kate Hovers. Getting all things right can make a real difference. Since we’ve used the Pruex Water Plus treatment via a dosatron and misted our bedding with Pruex Stabiliser, the E Coli scours have stopped and we have also ended the problematic blanket treatment of antibiotics.” Said Jack 

The ewes bedding is noticeably dryer. “When Aled told me to use a liquid product to dry up the bedding, if I’m honest, to start with I didn’t believe him, but it really does dry up the bedding. We don’t use a great deal less straw but I think that’s because the ewes seem to eat more of it than they used to. We aim to keep the ewes as clean as possible and the Pruex Stabiliser certainly helps in that respect”

Ingram Family Logie Durno

The Ingram’s are well known across the UK and further afield for their sheep enterprise at Logie Durno farm in Inverurie. The 3,500 strong ewe base of pedigree and cross breed ewes produce over 800 rams annually that are sold
 at their on farm sale, national society sales and NSA sales. The family produce rams for both the maternal and terminal market, with the pedigree and terminal flocks lambed indoors from December, with the indoor lambing concluding at the end of April.

 “The family being well known and respected within the industry are drivers of positive change to outdated practices” says Aled Davies founder of Pruex.

Ewes are lambed on a mix of straw and sawdust beds with ewes spending as little time indoors as possible. They are brought indoors once the first ewe from that cycle lambs outdoors. Ewes are lambed indoors for ease of management and for ease of data capture such as birth weights, parental details and ease of lambing recorded prior to turnout.

Gregor Ingram approached Pruex in 2019 with the aim of limiting antibiotic, chemical use and input cost, with a focus on preventing rather than curing disease.

The Pruex Five Point Plan was adopted in 2019:
• Water Plus treatment was applied via the farms borehole treating the whole water system.
• Pruex Stabiliser was misted daily on the bedding, loose pens and individual mothering pens.
• No corners were missed with the pet lamb group on a shepherdess feeding system also being treated.

The big difference seen by Gregor and the family was the reduction in the mastitis cases on the farm both immediately in the lambing shed and following turn out. “We had
 hardly any mastitis this year in the ewes, as toxic bacteria pressure was reduced. The ewes seemed to be leaving the shed a lot cleaner and healthier, and they have remained healthy throughout the year with the lambs and ewes also performing well.” The farm even noted an improvement
in the pet lambs with “batches weaning off the machines cleaner and healthier with much improved performance following weaning,” said Gregor.

The focus for the 2020 season will be to drive down antibiotic usage on the farm by further reducing the mastitis cases as well as a focus on lameness within the flock.” This should be a big focus for sheep farmers across the UK” states Gregor. “The family being well known and respected within the industry are drivers of positive change to outdated practices” says Aled Davies founder of Pruex.

The Perkins family farm at Dinas Island in West Wales and are one of the main ram producer farms for Innovis, with 500 Abermax stock ewes and a 1,000 strong Lleyn flock with 500 in the Aberfield SR program and 500 put to a Lleyn ram for pure breeding.

The ewes are housed in December for March lambing due to the harsh weather conditions confounded on Dinas Island by a lack of shelter, and are turned out following the recording of ewe and lamb data, such as ease of lambing and birth weights. Prior to implementing the Pruex 5 Point Plan the farm were using lime with straw bedding in an attempt to limit various health issues including joint ill. Pregnant ewes were moved out of their pens weekly and run through an external footbath in an attempt to combat lameness. The worst ewes being targeted and segregated for individual antibiotics treatment. Maintaining clean and dry bedding was a constant battle. Detailed record keeping highlighted the costs of culling heavily according to foot health. Repeat offending ewes with foot problems were culled from the flock increasing the number of ewe lamb replacements needed. Neil noted that prior to using the Pruex products the farm records magnified that foot treatments were the main health burden and were utilising a significant amount of time, resources and money.
Since using Pruex in the lambing shed and in the water supply from December 2018 onwards, the family have stopped using lime as well as foot bathing completely and have seen significant reductions in lameness and lamb infections such as joint ill which used to occur in 2 to 3% of lambs. Pruex Stabiliser is applied as a mist directly onto the bedding in the ewes pens as well as the individual mothering pens daily. Neil has made some rough calculations himself and believes that by drying up the bedding with the mist of Pruex Stabiliser the savings in straw alone equate to the cost of the Pruex products, and that other health benefits such as reduced lameness and lamb infections such as joint ill are a bonus. His antibiotic bill has reduced by £3,000 annually, a major objective of his flock health plan. “The sheep sector is a low net user of antibiotics when compared to other meat sectors, but do use heavily during the lambing period. It’s been the focus of our work for this sector at Pruex, and this type of reduction shows what can be achieved in a small amount of time when farmers have the determination and focus portrayed by the Perkins family”, said Aled Davies,
founder of the company.

Water treatment is done via a dosatron pump with the whole farm receiving treatment 365 days of the year. This incorporates into the rotational grazing program utilised with each water trough readily treated. The water troughs are routinely cleaned before fresh break moves and given an extra 300ml shock treatment of Pruex Water Plus plus as the trough refills. 

The detailed record keeping of foot treatments continues and in 2019 the total treatments on the farm have dropped by 68% and the total for 2020 in on track to mirror that improvement. This not only saves time and labour, but it has also reduced the culling rate on the farm due to a reduction in repeat offenders. The farm have also noted a significant reduction in joint ill cases which were
previously treated by catching lambs outdoors, with
problem cases injected with antibiotics. Since the 2019 lambing the number of joint ill cases have reduced greatly with only 3 lambs needing treatment annually.
The plan of action for the 2021 lambing season is to build on the knowledge gained over the last two lambing seasons. In addition to misting the bedding with Pruex Stabiliser and treating the water with Pruex Water Plus, and in order to reduce both workload and toxic bacterial loading on newborn lambs, Pruex Base Layer will be used instead of lime and straw in the mothering pens.
Pruex Base Layer is dust extracted chopped straw (2cm), treated at bagging with Pruex bacteria. It will be used in conjunction with Pruex Stabiliser to absorb moisture and populate good bacteria in the area where lambs need protection during the early stages of their lives.

Cows can get stressed when handled in a crush. If there are several cows that need treatment, the farmers arms and shoulders can get fatigued as well. The Easy-Boss-E is an Oral Distraction tool that takes stress away for farmer and animal.

Once inserted, the cow relaxes to chew its cudd. In the video, the cow is being given a Pruex Post Calving Bolus. This will help her clean post calving. The bolus is quite large, so the farmer inserts the Easy-Boss-E first to calm her, then administers the bolus using a bolus gun. She stops struggling once the Easy-Boss-E is inserted.

We specialise in solving problems on farm. To do so, we take our time to assess the causes of disease per building or per farm. Once these issues are identified, we assemble bespoke programmes with different packages of tools/products to attack the issues at source. We don't tend to treat symptoms, rather concentrate on the cause. Presentations to farming groups allow us to share what we learn.

FIND - FIX - TELL

A farmers experience of using Quietwean tags.The objective being to reduce stress at weaning. The results, less antibiotic use.

The following video gives some background into the development Quietwean tags.

At Pruex, we aim to lead the fight against Antimicrobial Resistance. (AMR). Communicating this problem to people is a challenge, as they don't seem to understand why the issue is called Antimicrobial Resistance, they always ask, why not call it Antibiotic Resistance? They really don't know that bacteria can develop resistance to Antiseptic products and get alarmed when they discover that bacteria can also develop resistance to Disinfectants.

Infection control, a method of cleaning, in hospitals, in homes, in schools, on farms have all concentrated on achieving sterility, but, we and our animals don't live in a sterile world. Minutes after cleaning, the void generated by disinfection is already being repopulated by bacteria and other micro organisms. At Pruex, we communicate a new and highly successful message. Our strategy is to populate the environments we live in with non infective bacteria. That is, good bacteria that doesn't make us or our animals sick. We know how to turn surfaces from being dominated by infectious bacteria into surfaces dominated by harmless bacteria for the long term. This makes the surfaces safe. People and animals then don't need antibiotics because they simply aren't infected by disease causing bacteria.

On farms we measure reductions around 70% in the amount of antibiotics used. On other farms we work to help the farmers achieve zero antibiotic use. We believe strongly that if an animal is infected with a bacteria that can be controlled by antibiotics, that the animal should be treated with the drug for welfare reasons. Prudent (PRU), as opposed to Excessive (EX), use of antibiotics - PRU EX.

Hospitals in countries like Canada, Australia, Germany, Benelux and Italy are already using this technology, and our work in homes and other public places ensure safe environments for those inhabitants.

Pruex work a One Health strategy. We work across all species, human, pet and food producing animals. Work with us, help us inspire others to act.

We saw this video online recently and include it within this document. It communicates the issue we face in terms of Antimicrobial resistance with particular reference to antibiotic resistance. Well done the people at visuallab.no that made the film.