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At Pruex, we aim to lead the fight against Antimicrobial Resistance. (AMR). Communicating this problem to people is a challenge, as they don't seem to understand why the issue is called Antimicrobial Resistance, they always ask, why not call it Antibiotic Resistance? They really don't know that bacteria can develop resistance to Antiseptic products and get alarmed when they discover that bacteria can also develop resistance to Disinfectants.

Infection control, a method of cleaning, in hospitals, in homes, in schools, on farms have all concentrated on achieving sterility, but, we and our animals don't live in a sterile world. Minutes after cleaning, the void generated by disinfection is already being repopulated by bacteria and other micro organisms. At Pruex, we communicate a new and highly successful message. Our strategy is to populate the environments we live in with non infective bacteria. That is, good bacteria that doesn't make us or our animals sick. We know how to turn surfaces from being dominated by infectious bacteria into surfaces dominated by harmless bacteria for the long term. This makes the surfaces safe. People and animals then don't need antibiotics because they simply aren't infected by disease causing bacteria.

On farms we measure reductions around 70% in the amount of antibiotics used. On other farms we work to help the farmers achieve zero antibiotic use. We believe strongly that if an animal is infected with a bacteria that can be controlled by antibiotics, that the animal should be treated with the drug for welfare reasons. Prudent (PRU), as opposed to Excessive (EX), use of antibiotics - PRU EX.

Hospitals in countries like Canada, Australia, Germany, Benelux and Italy are already using this technology, and our work in homes and other public places ensure safe environments for those inhabitants.

Pruex work a One Health strategy. We work across all species, human, pet and food producing animals. Work with us, help us inspire others to act.

We saw this video online recently and include it within this document. It communicates the issue we face in terms of Antimicrobial resistance with particular reference to antibiotic resistance. Well done the people at visuallab.no that made the film.

There are many farm inputs that dairy farmers can buy which add to the cost of their production. "One of the most expensive things a dairy farmer can do is to give poor quality water to their cows" said Aled Rhys Davies, managing director and founder of Pruex.

Pruex work with farmers to find out which bacterial colonies generate biofilm in their pipes and troughs. Armed with this information, Pruex suggest dose rates of their water product to help prevent biofilm formation. 

"We consistently get feedback on milk quality. Positive butterfat and protein modulation as a result of providing clean water. Common sense tells us that you can't get clean milk from dirty water. Our top producers value the extra income they can achieve from getting top quality water" Said Aled.

If you have a horrid slime on the walls of your water troughs, and/or within your water pipes then it would be worth speaking to Pruex. Call today on +441558668822

Our quest as humans to achieve almost sterile environments to live in has resulted in us putting great strain on our health. We have cleaned with chemical biocides, and have seen an increase in Fake Food that's highly processed to ensure consumer convenience. The skin and other organs suffer as a result. 

Pruex work on all areas needed to take pressure off. We work via Pruex Barn on agriculture, using soil bacteria to ensure a dry bed, clean air and water for livestock, and our agricultural arm of Pruex Body to work on the inside of the animals using plant material. Healthy animals are needed to form a healthy balanced diet.  Pruex Home is where we use soil bacteria to ensure healthy environments for humans and pets, and we have Pruex Body products, plant material to help on the inside of the body.

In this example, Acne caused the young girl pictured to loose confidence. Having identified the likely cause in her environment and diet, we recommended changes she could make to her lifestyle using Pruex Home and Body products.

We're delighted that she feels confident enough for us to publish her photos, and wish her well for her future.

Synbiotic skin care 

In humans, the skin is considered to be the largest organ and, like the internal organs, contains several layers of specialised cells (tissues) that function together. The condition of the skin sometimes provides important information about whether or not the body as a whole functions properly. Our skin is the first and most important barrier to the outside world and protects us against harmful influences and infections. 

Moreover, it has become clear in recent years that the skin carries a large number  of micro-organisms (= skin microbiome or skin flora) that fulfil an important function. When the skin flora or the skin are disturbed, this can lead to a large number of (serious) problems. 

The skin and its microbiome 

Human skin has an area of 2 square meters and consists of 3 main layers: the epidermis, dermis and hypodermis; each of which still consists of several sublayers with a specific function. Each square cm of the skin contains about 100 sweat glands, 10,000 cells and 200 nerve endings in addition to blood vessels! 

The skin has several important functions: 

• Protection against harmful germs and the outside world
  - Measure via the nerve endings of e.g. outside temperature
  - Temperature control via intensive blood flow
  - Moisture regulation via the sweat glands
  - Storage of fats, vitamin D and other vital substances
  - Absorption of oxygen or, for example, medicines via ointments or patches
  - Social function in which the colour and health of the skin play a role in human interaction 

In addition to the skin (structure) itself, recent research also shows that the microflora present on the skin (= skin microbiome) plays a very important role. A microbiome is the total number of micro-organisms (mainly bacteria) that are located somewhere; whether they work together as a community or not. The best known microbiome is that of humans and includes, for example, the micro-organisms present in our mouth, digestive system and on our skin. Even though these microorganisms do not all work together, they do determine the "state (or health)" of the place where they are located. A stable, healthy microbiome is therefore of great importance for our health and that of the entire environment. Human skin naturally contains millions of micro-organisms! 

Skin disorders 

The skin structure and its microbiome are both important to protect us from many harmful influences and infections. When one or both are damaged, there is a good chance that we will have skin or health problems. Very often these problems are directly or indirectly linked to microbiology. When the skin is physically damaged, certain microorganisms can suddenly cause infection, while not doing so on intact skin. 

Some of the most common skin disorders: 

• Acne: inflammation of the sebaceous glands with possible secondary infections of the wounds 
• Allergy: reaction of the skin to all kinds of external or internal substances
• Atopic eczema: chronic inflammation of the skin causing damage
• Dermatitis: acute skin infections with different causes 
• Dry skin: damage to the skin due to an incorrect water balance
• Shingles: inflammation of the skin due to the Varicella virus
• Psoriasis: disordered skin renewal process with unpleasant symptoms
• Fungal infections: inflammation of the skin due to infection with Candida or other fungi
• Staphylococcus infections: serious infections and inflammations with the Staphylococcus bacteria 
• Warts: skin damage from viral infections 

It is also possible that an underlying condition (e.g. cancer) has a negative effect on the skin, causing it to be damaged and thus causing additional problems. 

In the prevention and cure of most skin conditions, it is crucial to keep the skin structure and the skin microbiome in good condition! 

Classic soaps and disinfectants 

Until a few years ago, people were not yet aware of the great importance of the skin microbiome. The soaps, shower gels, shampoos that had been developed until then mainly aimed at cleaning the skin as powerfull as possible, often with very strong degreasing effect. On the one hand, such degreasing damages the skin itself, but especially also the natural microflora that is on the skin. This greatly disrupts the skin and its microbiome, causing them to lose their protective function. 

Disinfectants are absolutely harmful to the skin and its microbiome. These products date from the era of aseptics in which they wanted to kill all micro-organisms in order to obtain good hygiene. In the meantime, science has shown that a large number of micro-organisms exist that are useful or even necessary for our good health. Disinfectants also kill these good microorganisms and also create resistance among the bad germs. 

Classic chemical soaps and certainly disinfectants damage the skin and the microbiome, increasing the risk of skin problems! 

Synbio® skin cleansing and care 

After many years of research, Chrisal has developed a technology for skin cleansing and care that maximally respects the skin and its microbiome and keeps it in good condition! This patented (EP3210612A1) technology is based on synbiotics: 

Synbiotics: Probiotics: Prebiotics: 

the combination of probiotics and prebiotics.
good bacteria that improve human and animal health nutrients that stimulate the development of good bacteria 

Image of Prebiotics

Image of Probiotics

The Synbio® skin care products contain a high concentration of probiotics and prebiotics. The probiotics reduce the risk of infections and install a good protective microbiome on the skin. The prebiotics support and stimulate the growth and activity of naturally good skin bacteria. In addition, the probiotics are active dirt removers that clean the skin on a microscopic level. This leads to a permanent skin cleansing and therefore a smooth and healthy skin. 

The main goal is to prevent an unhealthy skin microbiome. Because the Synbio® products actively add high numbers of good bacteria (the probiotics) and stimulate the growth of existing good skin bacteria through the prebiotics, a very stable and healthy microflora is formed and maintained. 

This stable healthy skin microbiome provides many benefits, both preventive and curative. Academic research institutes have conducted extensive research into the effects of this technology, which makes the claims made clinically proven! 

BAD MICROFLORA WITH CLASSIC SOAPS AND DISINFECTANTS 

GOOD MICROFLORA WITH SYNBIO® SKIN CLEANSING AND CARE PRODUCT

For more information, please call us on +441558668822  

There are many types of bacteria present on planet earth. Of the ones we know about, the majority are harmless, some beneficial to health, but others exist that can cause disease in animals including us humans. Since the 1950’s, our medical and veterinary professionals have used antibiotic, biocidal (disinfectant), and antiseptic products to control these harmful types. But, these disease causing bacteria are developing resistance to these products. This is known as antimicrobial resistance (AMR), and is a major cause for concern globally. Disease pandemics are known to damage social and economic infrastructure. A viral pandemic could weaken peoples’ immune systems to a point that the patient has no defence against virulent pathogenic bacteria that can’t be controlled by biocides in our hospitals, and that can no longer be controlled within the patient by treatment with antibiotics,  due to AMR. Pruex aims to inspire change in our strategy and lead the fight against AMR using what nature has taught us. 

In nature, there is a balance of bacterial types, regulated by the way each colony jostles and competes for dominance. There is never a void, there is always bacteria. Humans and animals don’t live in sterile environments. The balance is maintained as healthy when there are more harmless bacteria than there are harmful types. If all types are removed, via heat, or chemical action, for example by disinfection, then a race to repopulate the void ensues. If the race is won by the harmful bacteria, then the risk of animals contracting disease increases. Soil is dominated by harmless bacteria, whereas faeces is dominated by harmful types. In nature, animals are surrounded by soil, and as long as they don’t contaminate their water, bedding or air with faecal bacteria, their risk of contracting bacterial disease is limited. 

 Pruex apply a one health approach to reduce the threat of AMR globally, working to help professionals in human and animal health sectors do all they can to ensure the good types of  bacteria win.

Human misuse of antibiotics and disinfectant is driving the threat of AMR, but press coverage seems to point the blame at veterinary use in agriculture. To succeed in our aim of reducing the risk of AMR, humans can’t divide opinion and concentrate blame on one section of our social and  economic infrastructure over another. We have to work as a team and target all areas of concern collectively. A one health approach.

In hospitals, “super bugs” are very problematic. People with no infections catching bacterial disease whilst in hospital. The infections caused by bacteria that are either resistant to disinfection, or that can survive disinfection by being protected in a biofilm, a nest of slime that disinfection can’t totally eradicate from surfaces. From their nest of slime, they quickly win the race to repopulate the void generated by the cleaning process. Biofilm also pose a health problem in our homes, offices, recreational establishments and schools. If soil isn’t dominant, good types of bacteria are not dominant, and a biofilm exists. The infective types of bacteria win the race over the good types. Pruex provide good bacteria in cleaning products that remove biofilm without creating a void and  reduce the risk of infective bacteria making people sick. If they’re not infected, they don’t need antibiotics. This reduces the risk of infective bacteria becoming resistant to disinfection and antibiotics.

The immune system has a role to play, for humans and animals alike. Age, stress levels, genetics, diet, exercise, air quality, temperature, humidity, water quality, mental health and wellbeing are all variables that can influence the effectiveness of the immune system in defending people and animals against infections. The role of colostrum in mammals or yolk in birds in ensuring passive immunity from mother to offspring can also determine the strength of the immune system. Pruex apply a two fold strategy to disease prevention, using non infective bacteria to ensure less risk of environmental infections, and dietary products to work with the immune system from within. Protecting from outside and inside the body.

Bacterial infections in our food production systems are problematic, reducing efficiencies, and adding costs to production. Sick animals don’t grow well. Post the second world war, the need for low cost food saw an intensification of agriculture to prevent starvation of human populations. As a result, animals have been kept in large numbers. So water systems have been developed to pipe water to animals. Biofilm is a major problem within these water systems. The tools used by veterinarians to limit the effect of infections have been antibiotics, disinfectants and antiseptics, but the threat of AMR requires a new strategy. Pruex provide dietary products to work from within the animals’ body and good bacteria in cleaning products for surfaces and water systems to remove biofilm without creating a void. This strategy reduces the risk of infective bacteria in the animals’ water and bedding infecting animals and generates lower levels of ammonia and carbon dioxide. Farmers and pet owners alike work with Pruex to ensure a  dry bed, clean air and water for their animals, reducing the risk of infection. If the animals aren’t infected, they don’t need antibiotics. This reduces the risk of infective bacteria becoming resistant to disinfection and antibiotics. Consumers can be confident that animals reared in a Pruex barn are healthier.

Pruex aims to lead the global fight against AMR. Please work with us.

With the outbreak of the Corona COVID19 virus worldwide, Pruex is receiving many questions about the effectiveness of its probiotic cleaning and personal care products. By means of this blog, we want to provide correct information on what to expect and how to use the Pruex products.

NOTE: NOT A SINGLE PRODUCT in the world can prevent direct transmission of this (or any) virus through aerosols (tiny particles when sneezing or coughing) from person to person. So, we need to focus on the indirect transfer through hands, surfaces or objects. Pruex products contain good bacteria for improved hygiene and protection. Upon application, the good bacteria stay on the surface (hard surface, textile, skin...) in order to provide two main benefits:
- Deep cleaning: The good bacteria produce enzymes that digest organic pollution in order to make the surface microscopically clean. The good bacteria remain active for several days continuously!
- Healthy microbiome: The good bacteria cover all surfaces (including skin) for a reduced risk of infection, as proven by clinical trials (Caselli 2018; PLOS ONE)

In order to benefit from this superior protection, Pruex advise the following
actions and products:

1) Surface cleaning. COVID19 may survive longer on surfaces that contain biofilm or a lot of organic pollution. Cleaning with any of the Pruex cleaning products will make sure that the surface becomes and remains free of organic pollution. The probiotics will keep cleaning the surface constantly! Such a clean surface will also improve the efficacy of disinfectants if needed.

Recommended products: Pruex Economic Pro for surfaces and Pruex Floor Cleaner.
Frequency of application: minimum of 2x per week; daily for kitchen and toilets

2) Hand hygiene. One of the most important direct ways of transferring COVID19 from one person to another is by means of the hands. Cleaning your hands with Pruex products will create a healthy skin microbiome on the skin to strongly lower the risk of pathogen transfer.

Recommended product: Pruex Hand Soap and Pruex Hand Gel.
Frequency of application: Several times a day after each contact with a contaminated surface, bathroom visit or hand shaking.

3) Objects/textile. It is not always possible to clean all surfaces/materials (such as textile) or objects. This leaves a possible hot spot for the corona virus. Pruex has an ultrasonic fogging device to cover all surfaces and objects with a good microflora to lower the risk of infections.

Recommended product: Probinano Home & Office mister (1 device per 50m2)
Frequency of application: Permanent through automatic timer function

  4) Personal protection. Besides a proper hand hygiene, one can also further protect oneself. It has been proven that the Corona COVID19 virus first infects the upper respiratory tract and sinuses. Making sure these areas also harbour a healthy microbiome will lower the risk of infection. Pruex has a system to promote such a healthy microbiome by means of inhaling Pruex good bacteria. The system is 100% safe and passed the official OECD403 tests.

Recommended product: Probinano Facial Mister
Frequency of application: Twice daily

The risk of infection can be reduced significantly by paying attention to some prevention measures such as proper hygiene.  If you should get infected, do not panic. COVID19 is no more lethal than flu. Avoid infecting others by keeping a distance and paying close attention to your hand hygiene and treatment of the room(s) you occupy with good bacteria.

Keep a strong immune function. This can be aided by using Allimed capsules.

Frequency of application. One capsule twice a day. See pack for details.

The need for clean hands and the use of alcohol hand gel is prominent in the news as a result of the Corona Virus issue. Pruex Hand Gel contains alcohol like every other type of product, but also contains non infective bacteria to immediately repopulate the hands post cleaning. A long lasting strategy. 

Cleaning with alcohol alone creates a void on the hands. The next thing you touch could be populating that void.

The Pruex Hand Gel comes in two sizes. One for your house 500ml, and one for your pocket/bag 150ml.

Dogs are said to be mans' best friend. In this example we see that ingenuity has made man a dogs' best friend. The picture below shows a dogs paw. She had a nodule on her paw that she kept on chewing which was surgically removed last year.  She was doing fine until it came back recently.  

The owner used the Allergen Spray and you see the difference within the week. 

Amazing result.

It does however raise an important question. Are we keeping our pets in environments that are bad for their health and optimise allergic reactions? At Pruex, we can help. We work out how to take environmental pressure away from our pets as well as people and farm animals.